Overview
The present invention relates to bioconjugate composition comprising curcumin and anticancer drug conjugated through heterobifunctional linkers that are delivered via the folate receptor to target specifically cancer and cancer stem cells to have maximum therapeutic efficacy. The method for the synthesis of bioconjugate constitute folic acid –Curcumin – anticancer drug that has been conjugated using acid labile linkers such as Thoimalaemic acid, N-ethoxy benzylimidazole (NEBI), amide, hydrazone linkage etc. The method for the synthesis of bioconjugate involves the conjugation of monoalkyne derivative of curcumin to heterobifunctional PEG such as N3PEG-COOH.